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KMID : 0368819920310020195
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Journal of the Korean Neuropsychiatr Association
1992 Volume.31 No. 2 p.195 ~ p.207
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Neuroendocrinological Tests in Psychiatric Disorders
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Abstract
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Psychoneuroendocrinology has become a major strategy in psychobiologic research. The foundation of this recent explosion of psychoneuroendocrinological research was 1aid much earlier, however, by important parallel developments in several fields.
The development in the 1960's of sensitive assays for pituitary hormones in tiny quantities of peripheral blood made multiple sampling techniques in humans possible. Also advances in psychoneuroendocrinology have gone far to elucidate the
neurotransmitter regulation of the hypothalamic secretions. Neuroendocrinological techniques have been applied successfully to the study of action of psychotropics on the human brain and to the exploration of neurotranmsitter abnormalities
possibly
underlying hormonal disturbances in psychiatric disorders. Although it has become obvious that all known pituitary hormones are under the control of the central nervous system. This control is still far from being fully understood. However,
considerable
amount of information exists on the basic substrate of the neuroendocrine system and there is a fair understanding of some of the phenomena it manifest.
In this overview. I tried to examine the dynamics of several major neurohormones that are regulated by neurotransmitters, and to introduce laboratory procedures and methods easily available in clinical practice. Also. A number of results drawn
from
neuroendocrinological studies regarding the two major psychoses(schizophrenia and mood disorder) are briefly described.
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